. 2020 Mar 5;37(4):1360–1380. doi: 10.1007/s12325-020-01269-2

Table 2.

Comparative studies evaluating the effect of antibiotic prophylaxis on the rate of wound infections

Article	Study type	Antibiotic regimen	Duration	Incidence SSI (%)	p value
Seagle et al. (1978) [15]	RCT (n = 50)	Cefazolin (n = 25)	1 day (n = 50)	16	< 0.05*
Seagle et al. (1978) [15]	RCT (n = 50)	Placebo (n = 25)	1 day (n = 50)	48	< 0.05*
Becker et al. (1979) [16]	RCT (n = 55)	Cefazolin (n = 32)	1 day (n = 55)	38	< 0.001*
Becker et al. (1979) [16]	RCT (n = 55)	Placebo (n = 23)	1 day (n = 55)	87	< 0.001*
Raine et al. (1984) [17]	RCT (n = 32)	Amoxicillin–clavulanate (n = 16)	2 days (n = 32)	25	< 0.025*
		Amoxicillin–clavulanate (n = 16)		75
		Placebo (n = 16)		75

RCT randomized controlled trial, n number of participants

*p < 0.05 is considered statistically significant