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. 2020 Mar 17;37(4):1407–1424. doi: 10.1007/s12325-020-01287-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Mechanism for the inducible apoptosis of senescent cells in INK-ATTAC mice. Zygotic cells are transfected with a construct encoding an FKBP/Casp8 complex plus a green fluorescent protein, all under the control of the Ink4a/Arf promoter (active only in senescent cells). Administration of the dimerizer AP20187 leads to conformation of an active caspase-8 and selective apoptosis of senescent cells in the whole organism. FKBP FK506 binding protein, IRES internal ribosomal entry site, GFP green fluorescent protein