Aging-associated diseases as a group are the main cause of morbidity and mortality worldwide.

Cellular senescence is a state of replicative arrest, suppressed apoptosis, and a typical secretory phenotype that accompanies aging.

Evidence from mouse models suggests that clearance of senescent cells improves health span and life span, limiting age-associated organ dysfunction.

Several small-molecule compounds (senolytics) have proven to lead to senescent cell clearance, and some of them are being tested in human trials.