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. 2020 Feb 28;11(3):259. doi: 10.3390/genes11030259

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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H19 regulates MYOD by affecting the enrichment of TDP43 at the MYOD promoter. (A) Chromatin Immunoprecipitation (CHIP)qPCR results revealed that TDP43 bound to the MYOD promoter. (B) and (C) Luciferase reporter assay of MYOD-promoter in PSCs transfected with either TDP43-pcDNA or TDP43 siRNA. (D) CHIP-qPCR results revealed that H19 knockdown significantly decreased the enrichments of TDP43 at the MYOD’s promoter. (E) Real-time PCR analysis of expression of MYOG, MYOD, and MYHC in PSCs after transfection with H19 siRNA or transfection with H19 siRNA and TDP43-pcDNA3.1. Mean values ± SD, n = 3. * means p < 0.05, ** means p < 0.01.