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. 2020 Mar 14;11(3):313. doi: 10.3390/genes11030313

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Details of the YARS2:p.Glu352Lys variant. (A) Representative Sanger electropherograms of a control, a carrier, and an affected dog illustrate the c.1054G>A variant. The amino acid translations are shown. (B) Evolutionary conservation. The glutamate at position 352 is highly conserved across all eukaryotes. (C) Three-dimensional structure of the human YARS2 protein in complex with an adenylate homolog [16,17,18]. The position of Glu352 is indicated in the right monomer. (D) Enlarged details of the structure in a space-filling model. The negatively charged carboxyl group of Glu352 is located at the surface of the tRNA binding domain.