Table 6.
Significantly enriched ordered pathways for overlapping endometriosis-migraine genes.
| Term ID for pathway | Pathway term name | Adjusted p-value | Genes |
| Source: Gene Ontology (Molecular function) | |||
| Interleukin-1 receptor binding | GO: 0005149 | 9.19 × 10−03 | IL36RN, IL37, IL36B, IL1B, IL1F10 |
| Source: Gene Ontology (Biological process) | |||
| Regulation of I-kappaB kinase and NF-kappaB signalling | GO: 0043122 | 1.90 × 10−02 | TRIM32, IL36RN, IL37, TMED4, IL36B, IL1B, RNF31, IKBKB, SHISA5, TANK, PARK2, IL1F10, ZDHHC17, GSTP1, DAB2IP, SLC35B2, TRIM13 |
| Source: Biological pathways (Kyoto Encyclopedia of Genes [KEGG]) | |||
| MAPK signalling pathway | KEGG: 04010 | 1.40 × 10−02 | IL1B, FGF18, NGF, IKBKB, MAP2K5, PTPN5, PDGFC, MAPK9, NRAS, PPP3CA, CACNA1E, FGF17, MAP2K6, FGF9, MET, RPS6KA4, FGFR4 |
| Source: Biological pathways (WikiPathways) | |||
| MAPK Signalling Pathway | WP: WP382 | 1.3 × 10−02 | FGF11, IL1B, FGF18, NGF, IKBKB, MAP2K5, PTPN5, MAPK9, NRAS, PPP3CA, CACNA1E, FGF17, MAP2K6, FGF9, RPS6KA4, FGFR4 |
| Focal Adhesion-PI3K-Akt-mTOR-signaling pathway | WP: WP3932 | 1.54 × 10−02 | FGF11, ITGB5, CREB5, PFKFB4, PPP2CA, DDIT4, FGF18, NGF, IKBKB, PTK2, PDGFC, SLC2A4, NRAS, CREB3L2, FGF17, FGF9, MET, FGFR4 |
| TNF alpha Signalling Pathway | WP: WP231 | 2.3 × 10−02 | PPP2CA, RFK, IKBKB, PTPRCAP, MAPK9, NSMAF, NRAS, TANK, MAP2K6 |