Table 1.
Different classes of HDACs, their co-factors, and their cellular locations.
| Co-Factor | Class | Members | Location |
|---|---|---|---|
| Zn+2-dependent | HDAC I | HDAC1 | Nucleus |
| HDAC2 | Nucleus | ||
| HDAC3 | Nucleus | ||
| HDAC8 | Nucleus | ||
| HDAC II | HDAC4 | Nucleus/cytoplasm | |
| HDAC5 | Nucleus/cytoplasm | ||
| HDAC7 | Nucleus/cytoplasm | ||
| HDAC9 | Nucleus/cytoplasm | ||
| HDAC6 | Cytoplasm | ||
| HDAC10 | Cytoplasm | ||
| HDAC IV | HDAC11 | Nucleus | |
| NAD+-dependent | HDAC III | SIRT1 | Nucleus/cytoplasm |
| SIRT2 | Nucleus | ||
| SIRT3 | Mitochondria | ||
| SIRT4 | Mitochondria | ||
| SIRT5 | Mitochondria | ||
| SIRT6 | Nucleus | ||
| SIRT7 | Nucleus |