Table 2. Top 20 enriched pathways of downregulated genes in MIM159 tobacco.

Analysis was based on the 2345 genes that were downregulated in MIM159 tobacco leaves more than 5-fold compared to wild type. These genes were referred to by the Arabidopsis counterpart sharing the highest level of sequence similarity, and the GO enrichment analysis was performed by agriGO (Du et al., 2010). The highest 20 enriched pathways were ranked by P-value. A pathway with a P-value ≤ 0.05 is considered as significantly enriched.

Pathway	GO Term	P-Value
Microtubule-based process	GO:0007017	6.60E−13
Cell cycle	GO:0007049	7.70E−12
Lipid localization	GO:0010876	4.90E−11
Postembryonic development	GO:0009791	1.50E−10
Transmembrane receptor protein Tyr kinase signaling pathway	GO:0007169	2.00E−10
Cell surface receptor linked signaling pathway	GO:0007166	2.80E−09
Cellular developmental process	GO:0048869	7.30E−09
Postembryonic morphogenesis	GO:0009886	1.80E−08
Cellular component morphogenesis	GO:0032989	9.50E−08
Tissue development	GO:0009888	2.10E−07
Cell morphogenesis	GO:0000902	2.40E−07
Response to radiation	GO:0009314	4.00E−07
Regulation of cell size	GO:0008361	7.40E−07
Regulation of cell cycle	GO:0051726	7.90E−07
Cell wall polysaccharide metabolic process	GO:0010383	8.30E−07
Regulation of cellular component size	GO:0032535	9.10E−07
Cellular component organization	GO:0016043	9.50E−07
Lipid metabolic process	GO:0006629	1.60E−06
Unidimensional cell growth	GO:0009826	1.70E−06
Developmental growth involved in morphogenesis	GO:0060560	1.70E−06