Figure 1.

Remorin proteins and their targeting to plasma membrane nanodomains. Remorins have an N-terminal intrinsically disordered region, a central coiled-coil domain, and a REM-CA. The intrinsically disordered region is regulated by posttranslational modification, such as phosphorylation, and possibly modulates interaction with many different proteins. The coiled-coil domain is an oligomerization domain and mainly contributes to remorin trimer formation and interactions with other proteins. REM-CA is required for both plasma membrane and nanodomain targeting via interaction with inner leaflet lipids such as sterols and PI4P.