Figure 11:

(a) Schematic diagram of the thermodynamic cycle for DDM. The binding free energy between receptor R and ligand L stands for $\text{Δ}{G}^o$. The binding free energy is calculated by $\text{Δ}{G}^o=-\text{Δ}{G}_{\text{restr}}^{RL}-\text{Δ}{G}_{\text{decoupl}}^{RL}+\text{Δ}{G}_{\text{restr}}^{R+L}+\text{Δ}{G}_{\text{decoupl}}^{R+L}$. (b) The modified thermodynamic path of DDM. The binding free energy is calculated by $\text{Δ}{G}^o=-\text{Δ}{G}_{\text{decoupli}}^{RL}-\text{Δ}{G}_{\text{restr}}^{\prime R}-\text{Δ}{G}_{\text{decoupl}2}^{RL}+\text{Δ}{G}_{\text{restr}}^{R+L}+\text{Δ}{G}_{\text{decoupl}}^{R+L}.$.