PD‐MC suppressed hepatic inflammation and oxidative stress in CCl4 induced mice. A–D) Hepatic expressions of CD68, TLR4, and NF‐κB p‐p65 were evaluated by immunochemical staining (n = 6) and Western blot assay (n = 4). E,F) Hepatic levels of inflammatory factors, IL‐1β, IL‐6, and TNF‐α, were measured by qRT‐PCR and ELISA. n = 6. G,H) Hepatic oxidative stress was evaluated by immunofluorescent staining of 4‐HNE and NOX‐4. n = 6. NS: no significance; *p < 0.05, **p < 0.01, and ***p < 0.001 versus mice induced by CCl4. #p < 0.05, ##p < 0.01, and ###p < 0.001 versus CCl4 induced mice treated with free polydatin. Dashed line squares: see Figure S15, Supporting Information, for the increased magnification.