Figure 3.

Pipeline used to develop classifiers for predicting pregnancy complications. To develop classifiers for predicting pregnancy complications, the plasma samples of pregnant women were collected before the diagnosis of pregnancy complications. The samples used for classifier construction were selected according to the gestational age of sampling and their follow‐up results. Additional details regarding the definition of pregnancy complications and corresponding controls are presented in Methods section. GA means gestational age. ^{a, b}, and ^c indicate participants from the Nanfang Hospital of Southern Medical University, Third Affiliation Hospital of Sun Yat‐Sen University, and Cangzhou People's Hospital, respectively. Plasma cfDNA samples collected from Nanfang Hospital were analyzed using the Illumina sequencing platform. Plasma cfDNA samples collected from The Third Affiliation Hospital of Sun Yat‐Sen University and Cangzhou People′s Hospital were analyzed using the Ion Proton sequencing platform.