Table 4.
Multivariable analysis of factors associated with in-hospital mortality among HF patients with Clostridioides difficile infection (CDI) according to the diagnosis position.
| Variable | Categories | Primary Diagnosis | Secondary Diagnosis | Any Position | |||
|---|---|---|---|---|---|---|---|
| Crude OR (95% CI) | Adjusted OR (95% CI) | Crude OR (95% CI) | Adjusted OR (95% CI) | Crude OR (95% CI) | Adjusted OR (95% CI) | ||
| Year | 2001–2005 | 1 | 1 | 1 | 1 | 1 | 1 |
| 2006–2010 | 1.22(0.77–1.96) | 1.14(0.70–1.85) | 0.99(0.82–1.19) | 0.93(0.76–1.12) | 1.02(0.86–1.21) | 0.96(0.81–1.15) | |
| 2011–2015 | 0.78(0.51–1.21) | 0.76(0.48–1.20) | 0.91(0.76–1.08) | 0.83(0.70–0.99) | 0.86(0.73–1.00) | 0.82(0.69–0.96) | |
| Sex | Female | 0.77(0.59–1.01) | 0.76(0.57–1.02) | 0.91(0.80–1.04) | 0.85(0.75–0.99) | 0.87(0.77–0.98) | 0.84(0.73–0.95) |
| Age groups in years | 40–64 | 1 | 1 | 1 | 1 | 1 | 1 |
| 65–74 | 4.19(1.23–14.23) | 5.69(1.59–20.42) | 1.27(0.91–1.77) | 1.39(0.99–1.96) | 1.41(1.04–1.93) | 1.58(1.14–2.18) | |
| 75–84 | 3.93(1.21–12.77) | 6.13(1.78–21.10) | 1.39(1.03–1.88) | 1.66(1.22–2.27) | 1.50(1.12–1.99) | 1.85(1.37–2.48) | |
| ≥85 | 5.06(1.56–16.44) | 8.80(2.55–30.33) | 1.78(1.32–2.39) | 2.28(1.67–3.11) | 1.91(1.44–2.54) | 2.55(1.89–3.43) | |
| CCI | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
| 1 | 1.54(1.06–2.24) | 1.89(1.27–2.83) | 1.19(1.00–1.42) | 1.33(1.11–1.59) | 1.25(1.07–1.47) | 1.41(1.19–1.66) | |
| ≥2 | 1.34(0.92–1.94) | 1.68(1.12–2.53) | 1.07(0.89–1.28) | 1.25(1.04–1.52) | 1.11(0.95–1.31) | 1.32(1.11–1.56) | |
| Hypercholesterolemia | Yes | 0.64(0.45–0.91) | 0.72(0.50–1.04) | 0.55(0.44–0.68) | 0.59(0.47–0.73) | 0.57(0.47–0.68) | 0.62(0.51–0.75) |
| Severity | Yes | 5.46(3.49–8.54) | 6.19(3.80–10.02) | 2.80(2.35–3.35) | 3.06(2.55–3.69) | 3.09(2.63–3.65) | 3.37(2.84–4.00) |
| Readmission | Yes | 1.07(0.82–1.39) | 1.09(0.82–1.43) | 1.31(1.14–1.51) | 1.42(1.23–1.64) | 1.21(1.07–1.37) | 1.33(1.18–1.52) |
| ER admission | Yes | 0.67(0.41–1.11) | 0.70(0.42–1.18) | 0.74(0.60–0.89) | 0.71(0.58–0.87) | 0.72(0.60–0.86) | 0.71(0.59–0.86) |
| Primary diagnosis | Yes | NA | NA | NA | NA | 0.83(0.72–0.97) | 0.93(0.79–1.08) |
CCI—Charlson Comorbidity Index. ER—Emergency room. OR—Odds ratio obtained using logistic regression models. 95% CI; 95% confidence intervals. Only those variable that showed a significant association are showed. NA—Not applicable.