Comparison 2. Subgroup analysis ‐ Study population (children vs. adults).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Patients with hospitalization for greater than10 days	7	1087	Risk Ratio (M‐H, Random, 95% CI)	0.65 [0.44, 0.95]
2.1.1 Adults	5	843	Risk Ratio (M‐H, Random, 95% CI)	0.65 [0.41, 1.03]
2.1.2 Children	2	244	Risk Ratio (M‐H, Random, 95% CI)	0.61 [0.24, 1.53]
2.2 Time to neutrophil recovery	5	794	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.34, 0.81]
2.2.1 Adults	4	608	Risk Ratio (M‐H, Random, 95% CI)	0.45 [0.29, 0.70]
2.2.2 Children	1	186	Risk Ratio (M‐H, Random, 95% CI)	0.80 [0.66, 0.97]
2.3 Duration of grade IV neutropenia	9	1135	Std. Mean Difference (IV, Random, 95% CI)	‐1.70 [‐2.65, ‐0.76]
2.3.1 Adults	7	891	Std. Mean Difference (IV, Random, 95% CI)	‐1.65 [‐2.75, ‐0.55]
2.3.2 Children	2	244	Std. Mean Difference (IV, Random, 95% CI)	‐1.93 [‐3.87, 0.02]
2.4 Time to recovering from fever	9	966	Std. Mean Difference (IV, Random, 95% CI)	‐0.49 [‐0.90, ‐0.09]
2.4.1 Adults	6	682	Std. Mean Difference (IV, Random, 95% CI)	‐0.56 [‐1.15, 0.03]
2.4.2 Children	2	244	Std. Mean Difference (IV, Random, 95% CI)	‐0.21 [‐0.46, 0.04]
2.4.3 Adults and Children	1	40	Std. Mean Difference (IV, Random, 95% CI)	‐0.69 [‐1.33, ‐0.05]