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. 2014 Oct 30;2014(10):CD003039. doi: 10.1002/14651858.CD003039.pub2

Comparison 4. Subgroup analysis ‐ Hospital discharge criteria (fever resolution).

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
4.1 Patients with hospitalization for greater than 10 days 5 784 Risk Ratio (M‐H, Random, 95% CI) 0.53 [0.32, 0.88]
4.1.1 Discharge after 48h of resolution of fever 2 324 Risk Ratio (M‐H, Random, 95% CI) 0.26 [0.04, 1.57]
4.1.2 Discharge after 72 hours of the resolution of fever 2 244 Risk Ratio (M‐H, Random, 95% CI) 0.61 [0.24, 1.53]
4.1.3 Discharge after 96 hours of the resolution of fever 1 216 Risk Ratio (M‐H, Random, 95% CI) 0.57 [0.39, 0.81]
4.2 Time to neutrophil recovery 5 794 Risk Ratio (M‐H, Random, 95% CI) 0.52 [0.34, 0.81]
4.2.1 Discharge after 24h of resolution of fever 1 68 Risk Ratio (M‐H, Random, 95% CI) 0.54 [0.35, 0.84]
4.2.2 Discharge after 48h of resolution of fever 2 324 Risk Ratio (M‐H, Random, 95% CI) 0.14 [0.04, 0.48]
4.2.3 Discharge after 72h of resolution of fever 1 186 Risk Ratio (M‐H, Random, 95% CI) 0.80 [0.66, 0.97]
4.2.4 Discharge after 96h of resolution of fever 1 216 Risk Ratio (M‐H, Random, 95% CI) 0.52 [0.37, 0.74]
4.3 Duration of grade IV neutropenia 8 1016 Std. Mean Difference (IV, Random, 95% CI) ‐1.39 [‐2.29, ‐0.50]
4.3.1 Discharge after 24 hours of resolution of fever 1 68 Std. Mean Difference (IV, Random, 95% CI) ‐0.53 [‐1.01, ‐0.04]
4.3.2 Discharge after 48 hours of resolution of fever 3 354 Std. Mean Difference (IV, Random, 95% CI) ‐1.87 [‐3.66, ‐0.07]
4.3.3 Discharge after 72 hours of resolution of fever 3 378 Std. Mean Difference (IV, Random, 95% CI) ‐1.38 [‐3.04, 0.28]
4.3.4 Discharge after 96 hours of resolution of fever 1 216 Std. Mean Difference (IV, Random, 95% CI) ‐0.44 [‐0.71, ‐0.17]
4.4 Time to recovering from fever 7 807 Std. Mean Difference (IV, Random, 95% CI) ‐0.27 [‐0.55, 0.01]
4.4.1 Discharge after 24 hours of resolution of fever 1 68 Std. Mean Difference (IV, Random, 95% CI) 0.00 [‐0.48, 0.48]
4.4.2 Discharge after 48 hours of resolution of fever 2 145 Std. Mean Difference (IV, Random, 95% CI) ‐0.72 [‐1.41, ‐0.02]
4.4.3 Discharge after 72 hours of resolution of fever 3 378 Std. Mean Difference (IV, Random, 95% CI) ‐0.14 [‐0.34, 0.07]
4.4.4 Discharge after 96 hours of resolution of fever 1 216 Std. Mean Difference (IV, Random, 95% CI) 0.00 [‐0.27, 0.27]