Comparison 5. Subgroup analysis ‐ Type of malignancy.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
5.1 Patients with hospitalisation for greater than10 days	7	1087	Risk Ratio (M‐H, Random, 95% CI)	0.65 [0.44, 0.95]
5.1.1 Mix	6	884	Risk Ratio (M‐H, Random, 95% CI)	0.58 [0.39, 0.87]
5.1.2 Hematological malignancies	1	203	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.81, 1.70]
5.2 Time to neutrophil recovery	5	794	Risk Ratio (M‐H, Random, 95% CI)	0.52 [0.34, 0.81]
5.2.1 Mix	4	726	Risk Ratio (M‐H, Random, 95% CI)	0.48 [0.26, 0.87]
5.2.2 Solid tumors	1	68	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.35, 0.84]
5.3 Duration of grade IV neutropenia	9	1135	Std. Mean Difference (IV, Random, 95% CI)	‐1.70 [‐2.65, ‐0.76]
5.3.1 Mix	7	948	Std. Mean Difference (IV, Random, 95% CI)	‐1.50 [‐2.50, ‐0.50]
5.3.2 Hematological malignancies	1	119	Std. Mean Difference (IV, Random, 95% CI)	‐4.55 [‐5.24, ‐3.86]
5.3.3 Solid tumors	1	68	Std. Mean Difference (IV, Random, 95% CI)	‐0.53 [‐1.01, ‐0.04]
5.4 Time to recovering from fever	9	966	Std. Mean Difference (IV, Random, 95% CI)	‐0.49 [‐0.90, ‐0.09]
5.4.1 Mix	6	739	Std. Mean Difference (IV, Random, 95% CI)	‐0.31 [‐0.62, 0.00]
5.4.2 Hematological malignancies	2	159	Std. Mean Difference (IV, Random, 95% CI)	‐1.32 [‐2.53, ‐0.12]
5.4.3 Solid tumors	1	68	Std. Mean Difference (IV, Random, 95% CI)	0.00 [‐0.48, 0.48]
5.5 Overall mortality	13	1335	Hazard Ratio (IV, Random, 95% CI)	0.74 [0.47, 1.16]
5.5.1 Mix	10	1108	Hazard Ratio (IV, Random, 95% CI)	1.03 [0.60, 1.75]
5.5.2 Hematological malignancies	2	159	Hazard Ratio (IV, Random, 95% CI)	0.32 [0.13, 0.78]
5.5.3 Solid tumors	1	68	Hazard Ratio (IV, Random, 95% CI)	0.14 [0.00, 6.82]