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. 2020 Mar 18;9(3):820. doi: 10.3390/jcm9030820

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of ponatinib and Notch-1 signaling inhibition on apoptosis and cell survival. Western analysis of cleaved caspase-3 (Panel (A)) and phosphorylated AKT (Panel (B)) expression in HUVECs treated with 1.7 nM of ponatinib or DMSO, in the presence or absence of 1 μg/mL neutralizing factor anti-Notch-1 antibody, with β-actin serving as a loading control. The bar graph represents for each value the mean ± S.D. from 3 separate experiments. Abbreviations: Pon, ponatinib; DMSO, dimethyl sulfoxide.