Table 1.

PICOS (population, intervention, comparison, outcome, and study design) criteria for inclusion of studies.

Parameter	Inclusion Criterion
Participants	Aging adults (55 years old and over)
Intervention	Acute and/or chronic (poly)phenols-rich supplementation
Comparison	Any
Outcome	Cognitive functions (e.g., overall cognition, psychomotor performance, executive function, processing speed, attention, language, verbal memory, and visual memory) and neuroprotective measures (e.g., brain perfusion, brain activity, cerebral hemodynamics, cerebral blood flow (CBF), neuroplasticity, and neuroinflammation)
Study design	Randomized controlled trial