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Evasion of the intracellular innate immunity response by hepatitis C virus (HCV) proteins. HCV NS3-4A, E2, NS5A, NS4B, p7, and core target several steps of the pattern recognition receptors (PRRs) signaling involved in HCV sensing, downregulating the expression of interferons (IFNs), proinflammatory cytokines and IFN-stimulated genes (ISGs), and consequently inhibiting the intracellular antiviral response.
