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. 2020 Mar 12;5(5):e134638. doi: 10.1172/jci.insight.134638

Figure 1. 7-T MR spectroscopy of the liver.

Figure 1

7-Tesla MR examinations in patients with active acromegaly (ACRO, n = 12) and healthy controls (CON, n = 17) showed (A) significantly decreased HCL (ACRO 1.0% [0.7%–1.8%] vs. CON 2.8% [1.5%–12.4%]) using Mann-Whitney U test (median ± IQR); (B) a lower unsaturation index in the liver (ACRO 8.4% [0.6%–16.3%] vs. CON 25.5% [18.9%–32.2%]) using a multivariable model adjusting for HCL (adjusted mean ± 95% CI); and (C) significantly increased hepatic ATP synthase activity (ACRO (0.28 s–1 [0.22–0.34 s–1] vs. CON 0.19 s–1 [0.14–0.24 s–1]), using a multivariable model adjusting for HCL (adjusted mean ± 95% CI). HCL, hepatocellular lipid content.