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. 2020 Mar 12;5(5):e131849. doi: 10.1172/jci.insight.131849

Figure 3. C3aR antagonist limits podocyte dysfunction in BTBR ob/ob mice.

Figure 3

Representative images and quantification of nephrin (A), α-actinin4 (B), and ILK (C) staining in BTBR WT and BTBR ob/ob mice treated with vehicle or C3aR antagonist. Renal structures and nuclei are stained with FITC-WGA-lectin (green) and DAPI (blue), respectively. Scale bars: 20 μm. Results are expressed as mean ± SEM (WT mice, n = 5; BTBR ob/ob+vehicle, n = 7–8; BTBR ob/ob+C3aR antagonist, n = 7–8), and ANOVA with Tukey multiple-comparisons test was used. *P < 0.05, **P < 0.01.