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. 2020 Mar 31;10:416. doi: 10.3389/fonc.2020.00416

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Copyright © 2020 Duan, Zhang, Li, Pang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of miR-155 inhibitor on mechanical and cold sensitivity. Paw withdrawal threshold (PWT) and cold sensitivity expressed as time spent on the cold plate (%) were examined in control rats and BTZ rats. (A) PWT was smaller in BTZ than in control rats at different time courses. Intrathecal injection of miR-155 inhibitor (3 μg each day over three consecutive days), but not its scramble, increased PWT in BTZ rats 1 day after its injection. (B) showing that time spent on the cold plate was less in BTZ rats than in control rats. MiR-155 inhibitor elevated % time spent on the cold plates in BTZ rats 1 day after its injection. Mir-155 inhibitor scramble had no effects on % time spent on the cold plates in BTZ rats. *P < 0.05, BTZ rats vs. control rats. #P < 0.05, BTZ rats with inhibitor vs. BTZ rats and BTZ rats with scramble. The number of rats in each group was shown on the figure.