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. 2020 Mar 31;10:416. doi: 10.3389/fonc.2020.00416

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Copyright © 2020 Duan, Zhang, Li, Pang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of blocking TNFR1 and TRPA1 on mechanical and cold sensitivity. TNF-α signal was inhibited by pentoxifylline (PTX; 10 μg each day over three consecutive days). TRPA1 was blocked by administration of HC030031 (5 μg each day over three consecutive days). (A) PWT was smaller in BTZ than that in control rats for all time courses. As compared with controls, intrathecal injection of miR-155 mimics (3 μg each day over three consecutive days) significantly decreased PWT, and the effects of miR-155 mimics were attenuated by injection of PTX and HC030031. (B) showing that % time spent on the cold plate was less in BTZ rats and in rats with injection of miR-155 mimics. PTX and HC030031 attenuated the effects of miR-155 mimics. *P < 0.05, control rats vs. control rats with mimics; #P < 0.05, rats with mimics vs. rats with mimics plus PTX or mimics plus HC030031. The number of rats in each group was shown on the figure.