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Brain overgrowth in Pten conditional heterozygous mice is rescued in Pten and Ctnnb1 double conditional heterozygous mice. Graph showing brain mass in Control, Emx1-Cre+; Ptenloxp/+, Emx1-Cre+; Ptenloxp/+; Mtorloxp/+, and Emx1-Cre+; Ptenloxp/+; Ctnnb1 loxp/+ mice. One-way ANOVA and Tukey’s posthoc tests were used. F(3,12) = 7.89, P = 0.004. *P < 0.05, and **P < 0.01. n.s. indicates no significant difference. N = 4 animals per genotype.
