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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Autism Res. 2019 Aug 23;12(10):1463–1471. doi: 10.1002/aur.2186

Figure 4.

Figure 4.

Neuronal hyperactivity in Pten conditional heterozygous mice is corrected in Pten and Mtor double conditional heterozygous mice. (A) Schema showing the procedure of social exposure. (B) Representative images of c-fos staining in the prelimbic cortex (PrL) and basolateral amygdala (BLA) of socially exposed mice. Scale bar: 100 μm. (C and D) Quantification of c-fos+ neurons in the PrL(C) and BLA (D) of socially exposed mice. One-way ANOVA and Tukey’s post hoc tests were used. *P < 0.05. n.s. indicates no significant difference. N = 7 animals per genotype. F(3, 24) = 8.25, P = 0.0006 (C); F(3, 24) = 7.462, P = 0.0011 (D).