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. 2020 Mar 20;9(3):856. doi: 10.3390/jcm9030856

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Role of extracellular vesicles in normal and abnormal hematopoiesis. Extracellular vesicles from BM-MSCs inhibit apoptosis and differentiation of HSPCs and induce engraftment of precursor cells in the BM niche. BM-MSC-derived exosomes from patients with multiple myeloma increase cell proliferation, viability, and chemo-resistance and facilitate tumor growth and cell migration. BM-MSC-derived exosomes from patients with Acute Myeloid Leukemia modulate chemo-resistance in cell lines. BM-MSC-derived micro-vesicles from patients with low-risk myelodysplastic syndromes increase cell viability and clonogenic capacity of CD34⁺ cells from healthy donors. Abbreviations: AML: acute myeloid leukemia, BM-MSCs: bone marrow mesenchymal stromal cells, EVs: extracellular vesicles, HSPC: hematopoietic stem and progenitor cells, MDS: myelodysplastic syndromes, MM: multiple myeloma, MVs: microvesicles, HPSCs: human hematopoietic stem and progenitor cells.