Table 3.

Trend, univariate analysis, and ROC curve analysis of the discriminant metabolites in CSF samples.

	CSF
	METABOLITES	RR vs. PP	p-Value	Holm–Bonf. Correction	ROC-CURVE
					AUC	Std. Error	CI	p-Value
FIA-MS/MS	-lysoPC a C20:4	+	0.02	ns	0.74	0.09	0.55–0.93	0.02
	-PC aa C34:2	-	0.04	ns	0.71	0.08	0.53–0.88	0.04
	-PC aa C36:5	-	0.03	ns	0.72	0.09	0.54–0.90	0.03
	-PC aa C38:5	-	0.02	ns	0.73	0.09	0.55–0.90	0.03
	-PC aa C42:0	-	0.009	ns	0.78	0.08	0.61–0.94	0.01
	-PC ae C34:3	-	0.04	ns	0.71	0.09	0.53–0.89	0.04
	-PC ae C38:4	-	0.03	ns	0.72	0.08	0.55–0.89	0.03
	-PC ae C40:2	-	0.007	ns	0.78	0.08	0.62–0.93	0.008
	PC ae C42:2	-	0.004	0.04	0.79	0.07	0.64–0.95	0.005
	SM(OH) C 22:1	-	0.010	ns	0.77	0.08	0.6–0.93	0.01
	SM(OH) C 22:2	-	0.01	ns	0.76	0.08	0.6–0.92	0.01
LC-MS/MS	HIS	+	0.0004	0.001	0.89	0.06	0.77–1	0.0009
	ORN	-	0.01	0.010	0.79	0.08	0.63–0.96	0.03
	PHE	+	0.03	0.010	0.75	0.09	0.57–0.93	0.03
	THR	+	0.001	0.002	0.86	0.07	0.71–1	0.002

+ or - indicates a higher or lower level of the metabolite in RR vs PP group.