Table 2.
Role of endogenous IL-12 versus other p40-dependent proteins in type-1 response induction in different murine infection modelsa
| Infection model |
Type-1 response induction |
Refs | |
|---|---|---|---|
| IL-12-dependentb | Dependent on other p40 cytokinesc | ||
| Leishmania major | + | − | [4] |
| Trypanosoma cruzi | + | − | [63] |
| Trypanosoma brucei brucei | + | − | F. Brombacher et al., unpublished |
| Cryptococcus neoformans | + | + | [40] |
| Salmonella Enteritidis | |||
| 50 cfu | − | + | [41] |
| 500 cfu | − | + | |
| 5000 cfu | − | + | |
| >10 000 cfu | + | − | |
| Francisella tularensis | − | + | [64] |
| Mycobacterium tuberculosis, Mycobacterium bovis BCG | + | + | 26, 27 |
| Listeria monocytogenes | +/−d | + | [65], F. Brombacher et al., unpublished |
| Sendai virus | − | + | [29] |
| Murine cytomegalovirus (MCMV) | − | + | [55] |
| Vesicular stomatitis virus (VSV), lymphochoriomeningitis virus (LCMV) | − | − | [56], H. Pircher et al., unpublished |
| Herpes virus (pseudorabies, HSV-1, bovine herpes virus 1 and 5) and corona virus (murine hepatitis virus) | − | − | [54], M. Suter et al., unpublished |
a
Abbreviations: BCG, bacillus Calmette–Guérin; cfu, colony forming units; HSV-1, herpes simplex virus-1; IL-12, interleukin-12; NK, natural killer.
b
Endogenous IL-12 essential.
c
Endogenous p40-dependent proteins different from IL-12 involved.
d
Endogenous IL-12 only required at high infective doses for NK-cell activation.