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. 2020 Apr 8;15(4):e0231418. doi: 10.1371/journal.pone.0231418

Fig 8. Proposed model of TERT transcriptional regulation.

Fig 8

Regardless of MF at the TERTp methylation region, both keratinocytes and melanocytes do not show TERT expression. In TERTp-mutated cell lines, an intermediate MF positively correlated with chromatin accessibility, in combination with C228T/C250T TERT mutations allows monoallelic TERT expression. In TERTp-WT cell lines, the MF is close to 100% with a significantly higher chromatin accessibility leading to high expression levels. Chromatin schemes adapted from Schwartz et al. [26].