Table II.
Six-month changes in six-minute walk and treadmill walking distance among participants with peripheral artery disease in randomized trials
| Control Group | Intervention Group | |||||
|---|---|---|---|---|---|---|
| Baseline | 6-month follow-up | 6-month change | Baseline | 6-month follow-up | 6-month change | |
| SILC randomized trial of supervised treadmill exercise | ||||||
| N=44 | N=47 | |||||
| Six-minute walk distance (meters) | 322.4 (87.1) | 307.7 (93.1) | −14.8 (57.1) | 326.1 (89.3) | 347.3 (80.8) | +21.2 (47.7) |
| Maximal treadmill walking distance (meters) | 328.2 (218.4) | 363.6 (234.1) | +35.5 (138.0) | 386.6 (250.0) | 605.3 (304.4) | +218.7 (203.4) |
| Correlations between treadmill and 6-minute walk | 0.483 P<0.001 | 0.746 P<0.001 | 0.510 P<0.001 | 0.566 P<0.001 | 0.659 P<0.001 | 0.145 P=0.3314 |
| GOALS randomized trial of home-based exercise | ||||||
| N=87 | N=86 | |||||
| Six-minute walk distance (meters) | 354.5 (93.2) | 349.2 (102.0) | −5.3 (56.4) | 356.0 (96.9) | 399.1 (102.1) | +43.2 (69.0) |
| Maximal treadmill walking distance (meters) | 392.9 (257.5) | 419.8 (285.5) | +26.8 (160.5) | 413.5 (254.3) | 495.8 (323.2) | +82.4 (174.0) |
| Correlations between treadmill and 6-minute walk | 0.677 P<0.001 | 0.730 P<0.001 | 0.201 P=0.062 | 0.595 P<0.001 | 0.669 P<0.001 | 0.201 P=0.064 |
| RESTORE randomized trial | ||||||
| N=20 | ||||||
| Six-minute walk distance (meters) | 352.8 (72.0) | 339.0 (86.7) | −13.7 (38.7) | |||
| Maximal treadmill walking distance (meters) | 457.4 (250.2) | 479.0 (262.2) | +21.5 (1115) | |||
| Correlations between treadmill and 6-minute walk | 0.684 P<0.001 | 0.858 P<0.001 | −0.021 P=0.932 | |||
| PROPEL randomized trial | ||||||
| N=44 | N=94 | |||||
| Six-minute walk distance (meters) | 342.9 (89.5) | 330.8 (96.7) | −12.1 (67.6) | 338.8 (101.4) | 367.6 (97.5) | +28.8 (66.8) |
| Maximal treadmill walking distance (meters) | 365.3 (187.7) | 383.9 (208.1) | +18.6 (125.8) | 355.3 (257.2) | 600.4 (305.7) | +245.1 (234.3) |
| Correlations between treadmill and 6-minute walk | 0.617 P<0.001 | 0.705 P<0.001 | 0.330 P=0.029 | 0.6500 P<0.001 | 0.7728 P<0.001 | 0.3422 P<0.001 |
| All participants randomized** | |||
|---|---|---|---|
| N=467 | |||
| Baseline | 6-month follow-up | 6-month change | |
| Six-minute walk distance (meters) | 340.0 (93.7) | 351.5 (99.7) | 11.5 (63.7) |
| Maximal treadmill walking distance (meters) | 376.9 (241.9) | 486.4 (293.7) | 109.5 (200.3) |
| Correlations between treadmill and 6-minute walk | 0.616 P<0.001 | 0.698 P<0.001 | 0.297 P<0.001 |
*
Data shown are means (standard deviations).
**
Includes participants in SILC randomized to strength training- therefore sample size is greater than the combined sample sizes from other cells in the table.