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Low-grade well-differentiated pancreatic neuroendocrine tumors (PanNETs). A, Grade 1 PanNET: small cells with finely granular cytoplasm and classic salt-and-pepper chromatin, arranged in a trabecular pattern. C, Grade 2 PanNET. B and D, Ki-67 less than 3% and 3% to 20% classifies these PanNETs into grades 1 and 2, respectively (hematoxylin-eosin, original magnification ×200 [A and C]; original magnification ×100 [B and D]).
