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. Author manuscript; available in PMC: 2020 Apr 8.
Published in final edited form as: Radiat Res. 2018 Aug 22;190(5):538–557. doi: 10.1667/RR15099.1

FIG. 6.

FIG. 6.

Radiation-induced senescence in H460wt and H460crp53 cells. Panel A: Beta-galactosidase staining and cell morphology. Beta-galactosidase staining indicating the induction of senescence by exposure (6 Gy) in both cell lines (scale bar = 20 μm). Panel B: Quantification of senescence. C12FDG staining and flow cytometry to quantify the extent of senescence in H460wt cells and H460crp53 cells. Panel C: Influence of radiation on levels of p21 associated with senescence. Western blot showing increased p21 induced by radiation in the H460wt cells but not the H460crp53 cells. Unless stated otherwise, data are from three independent experiments. *P < 0.05, control vs. irradiated group.