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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Adv Mater. 2019 Aug 18;32(13):e1902004. doi: 10.1002/adma.201902004

Figure 6.

Figure 6.

The design and results of hypoxia-responsive microneedle patch for insulin delivery. (a) Schematic of the glucose-responsive microneedle patch for insulin delivery. (b) Insulin release from nanoparticles was promoted with increased glucose concentration. The data were presented as mean ± SD (n=3). (c-d) Representative SEM (c) and fluorescence (d) images of microneedle patch loaded with FITC-labeled insulin. (e) Insertion of microneedle patch into skins of mice. (f) Blood glucose regulation of the microneedle patch was validated in type 1 diabetic mouse model. (g) Plasma insulin levels of mice treated with various microneedle patches. Data were presented as mean ± SD (n=5). *P < 0.05 for treatment efficacy of GRV(E+I) loaded microneedle array patch compared with GRV(1/2E+I) or GRV(E+I) loaded microneedle array patch. Reproduced with permission.[8b] Copyright 2015, National Academy of Sciences.