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. 2020 Apr 8;6(15):eaaz4232. doi: 10.1126/sciadv.aaz4232

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

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Fig. 6 — (A) Schematic of three conditions in LC opto-silencing arousal threshold experiments. Top: Presentation of sound (S) only (85-dB SPL); middle: same sound played simultaneously with laser stimulation (SL); bottom: same sound played 2 s after laser onset (SafterL). Laser duration was continuous for 5 s. (B) Probability of awakening as a function of the three conditions in rats expressing stGtACR2-fRed (blue, n = 6 rats) and mCherry control (gray, n = 5 rats) in NREM sleep (left) and REM sleep (right) (*P < 0.05 and **P < 0.01, paired t test). (C) Probability of awakenings from NREM sleep in each session per rat expressing stGtACR2-fRed. On average, per session and for each condition (S/SL/SafterL), 71 trials occurred during NREM sleep, and 20 trials occurred during REM sleep.