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. 2020 Apr 8;6(15):eaay5969. doi: 10.1126/sciadv.aay5969

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 1 — (A) urinary and (B) plasma metabolic profiles of infants from Peru (PE), Bangladesh (BG), and Tanzania (TZ). The heat map presents the correlation coefficient (r) obtained from PLS models: Blue colors indicate a negative association with age, and reds represent metabolic shifts positively associated with infant aging. (C) Mean effect size of age-discriminatory urinary metabolites on the PA based on children with healthy growth trajectories. The effect size is depicted as the estimated change in PA for each SD change in a metabolite concentration. Color indicates cohort site, and the size of the symbols indicates the percentage PA variance explained.