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. Author manuscript; available in PMC: 2020 Apr 8.
Published in final edited form as: Dev Dyn. 2018 Oct 11;248(1):118–128. doi: 10.1002/dvdy.24672

Figure 2.

Figure 2.

Upon differentiation, undifferentiated pluripotent stem cells (A) can be directed towards retinal cell fates following several steps that resemble normal developmental stages. First, they develop into a neural epithelium (B) that evaginates to form optic vesicle-like structures (arrows in C), and finally optic cup-like structures (arrows in D). The retinal progenitors can then differentiate into RGCs (E). The arrows in E show fluorescently-labeled RGCs (green) in a 10-day retinal organoid. Abbreviations: OV: optic vesicles, OC: optic cups, RGC: Retinal Ganglion Cells. Scale: 100 microns