Figure 2.
Metabolic impact of energy starvation.
(A and C) Partial least square-discriminant analyses (PLS-DA) reveals significant impact of both glucose starvation and glucose starvation in the absence of Ca2+ in red blood cells (RBCs) and supernatants, respectively. (B and D) Top 25 significant metabolites following starvation stress by ANOVA in RBCs and supernatants, respectively. Key metabolites are highlighted in the dot plots in the centre of the figure, colour-coded as per the legend on the right-hand side of the figure.
Ach: acetylcholine; ATP: adenosine triphosphate; GSH: glutathione; PS: phosphatidylserine; RibP: ribose phosphate; 6PG: 6-phosphogluconolactone.