FIGURE 4.

Impaired type I IFN signaling leads to a reduction in lung inflammation in adult mice. C57BL/6, IFN-β KO, STAT1 KO, and STAT2 KO mice (n ≥ 4 per group) were euthanized on day 7 postinoculation with B. pertussis or PBS sham inoculum, and lungs were dissected for assessment of outcomes. (A) Bacterial burdens. (B) Inflammatory pathology scores assessed from lung histology sections. Data are representative of at least two independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 by two-way ANOVA.