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. Author manuscript; available in PMC: 2020 May 12.
Published in final edited form as: Nature. 2019 Oct 9;574(7780):707–711. doi: 10.1038/s41586-019-1650-0

Figure 1. – Highly recurrent mutations of the U1-snRNAs in Shh-MB.

Figure 1. –

a) Cartoon illustrating the number and subgroup specific distribution of somatic mutations in the U1-snRNA genes. U1-snRNA sequence conservation scores as determined by Rfam database.

b) Secondary structure of the mutant U1-snRNA. The red circle identifies the location of the hotspot mutation. The yellow and green rectangles indicate the 5′ splice site recognition site and the Sm protein binding site respectively. Numerals I to IV indicate stem-loops.