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. 2020 Feb 14;39(15):3179–3194. doi: 10.1038/s41388-020-1207-6

Fig. 4. PTGES/PGE2-mediated recruitment of MDSCs is essential for immune suppression.

Fig. 4

a Twenty three-factor detection of supernatant medium from SJT-1601 and SJT-1601-ko-Ptges cells. b Representative FACS images for G-MDSCs and M-MDSCs staining in C57BL/6-WT and Gprc5a-ko mice tumor lung tissues (n = 5). c Statistical analysis of b. d Representative FACS images for T cells staining in C57BL/6-WT and Gprc5a-ko mice tumor lung tissues (n = 5). e Statistical analysis of d. f, g Recruit MDSCs experiment under different culture conditions by transwell experiments (n = 3). h–j T-cell-mediated cytotoxicity was assessed in SJT-1601-ko-Ptges cells with or without the condition medium of SJT-1601 and SJT-1601-ko-Ptges cells (n = 3). ns, not significant; *p < 0.05; **p < 0.01; ***p < 0.001.