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. 2020 Feb 14;39(15):3179–3194. doi: 10.1038/s41388-020-1207-6

Fig. 5. PTGES targeting restores host immunity, and inhibits lung metastasis.

Fig. 5

SJT-1601 cells were i.v. injected into Gprc5a-ko mice and Cay10526 was i.p injected according to the prescribed method (n = 5). a Model diagram of targeting Ptges with Cay10526 in Gprc5a-ko mice lung metastasis model. b ELISA kit analysis of the secretion of PGE2 in mice lung tissues. c Representative images of lung tissues stained with H&E. d Number of metastatic nodules of b. e Representative FACS images for G-MDSCs and M-MDSCs staining in tumor lung tissues. f Statistical analysis of e. g Representative FACS images for stained TAMs cells in tumor lung tissues. h Statistical analysis of g. i Representative FACS images for stained NK cells in tumor lung tissues. j Statistical analysis of i. k Representative FACS images for stained T cells in tumor lung tissues. l Statistical analysis of k. m Representative images of lung tissues with IHC staining for CD8 in control and Cay10526 treatment mice lung tissue, scale bar = 400 μm. ns, not significant; *p < 0.05; **p < 0.01; ***p < 0.001.