Fig. 3. Acv3UTR acts as a sponge to sequester miR-590-5p.
a Schematic diagram of RNA-pulldown study. b, c Five enriched microRNAs by acv3UTR pulldown. MiR-938 was used as a negative control. The five acv3UTR-enriched microRNAs were not enriched by acvr1B 5’UTR (d, e) or ORF (f, g) pulldown. h Heatmap showed the expression of five acv3ʹUTR-enriched microRNAs in 60 pairs of GC clinic samples with high acv3UTR expression. The expression of miR-590-5p (i), miR-199a-5p (j), miR-199b-5p (k), miR-145-5p (l) and miR-760 (m) in 60 pairs of GC clinic samples. ***P < 0.001 (paired t-test, two tailed).