Table 1.
Effect of different combinations of stilbene derivatives with fluconazole (FLC) against C. albicans NR-29448.
| Stilbenes drugs | MIC (µg/ml) | ΣFICIa | Interaction | |||
|---|---|---|---|---|---|---|
| FLC | Stilbenes drugs | |||||
| Alone | Combined | Alone | Combined | |||
| Clomiphene | 256 | 2 | 8 | 2 | 0.26 | SYN |
| Tamoxifen | 2 | 16 | 4 | 0.26 | SYN | |
| Toremifene | 2 | 8 | 2 | 0.26 | SYN | |
| Hexestrol | 1 | 8 | 4 | 0.50 | SYN | |
| Diethylstilbestrol | 1 | 4 | 2 | 0.50 | SYN | |
| Ospemifene | 2 | >256 | 2 | 0.02 | SYN | |
| Raloxifene | 2 | 64 | 16 | 0.26 | SYN | |
| Resveratrol | 8 | > 256 | 128 | 0.53 | ADD | |
| cis-stilbene | 2 | > 256 | > 256 | 1.01 | IND | |
aΣFICI (fractional inhibitory concentration index) values, rounded to the nearest two decimal places, were used to measure the interaction between the tested combinations. ΣFICI interpretation corresponded to the following definitions: synergistic (SYN), ΣFICI ≤ 0.50; additive (ADD), ΣFICI > 0.50 and ≤ 1; and indifference (IND), ΣFICI > 1 and ≤ 4.