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. 2020 Apr 8;10:6058. doi: 10.1038/s41598-020-62961-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Stratified analysis of progression-free and overall survival by variables. Kaplan–Meier curve of (a) PFS and (b) OS in patients who were previously treated with or without anti-VEGF therapies, (c) PFS and (d) OS in patients with different NLR levels, (e) PFS and (f) OS in patients with or without CA19-9 decrease, and (g) PFS and (h) OS in patients with or without HFS. PFS, progression-free survival; OS, overall survival; VEGF, vascular endothelial growth factor; NLR, neutrophil/lymphocyte ratio; carbohydrate antigen 19-9, CA19-9; HFS, hand-foot syndrome; HR, hazard ratios; CI, confidence interval.