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. 2020 Apr 8;11(4):224. doi: 10.1038/s41419-020-2415-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Bar plot shows the SNAI2, mRNA expression between high and low ASPP1 groups in colorectal adenocarcinoma (TCGA, Nature 2012) data. **P < 0.01. b The scatter plot for the correlation between SNAI2, mRNA expression (RPKM) (log10) and ASPP1, mRNA expression (RPKM) (log10) (Pearson’s correlation (r) = −0.2679 and P = <0.0001). c Heat-maps of the columns indicate each individual sample in high and low PPP1R13B (ASPP1) groups across each mRNA in TCGA colorectal adenocarcinoma data, which obtained from cBioportal website. Rows indicates mRNA expressions (RNASeq, RPKM). Dark blue colour indicates low expression of mRNA and dark pink colour illustrates highly expressed mRNAs. Unpaired t-test was analysed to find the significantly different mRNAs in colorectal adenocarcinoma (TCGA, Nature 2012) dataset. n represents the number of samples in each group. d The genes that were upregulated in high ASPP1 group was analysed in ToppGene Suite website to show which pathways are regulated. Histogram shows NF-κB related pathways. Y-axis shows the pathways and top x-axis and bottom x-axis show the number of shared mRNAs in each pathway and −log10 (P value), respectively.