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. 2020 Apr 8;11(4):225. doi: 10.1038/s41419-020-2422-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Upregulation of CLDN4 expression in SMMC7721-CLDN4 cell is assessed by Western blotting. B Transwell (B1) and wound-healing (B2) assay analysis of migration and invasion properties of SMMC7721-CLDN4 and SMMC7721-control cells. Scale bars: 250 μm (wound-healing) and 75 μm (transwell). C In vivo metastasis assays, (C1) Lung representative morphology and H&E staining, (C2) incidence of lung metastasis, (C3) number of metastatic lung foci, and (C4) overall survival of nude mice in SMMC7721-CLDN4 and SMMC7721-control groups (n = 10) are shown. Scale bars: 250 μm (low magnification) and 100 μm (high magnification). Data are presented asmean±S.D for three independent experiments. *P < 0.05.