Table 4.
Clinical outcomes of hypothermic oxygenated perfusion and control organs.
| Kidney | HOPE (N = 10) | Control (N = 30) |
Odds ratio/Effect size (CI interval) |
p value |
|---|---|---|---|---|
| PNF, n (%) | 0 (0%) | 1 (3.3%) | 0.9667 OR (0.3506–2.6656) | 0.9478 |
| DGF, n (%) | 2 (20%) | 12 (40%) | 0.7500 OR (0.2501–2.2489) | 0.6076 |
| Creatinine at 5 day post-transplant, media (SD) | 3.5 ± 2 | 4.1 ± 2.6 | − 0.24 ES (−0.96 to 0.48) | 0.4572 |
| eGFR on dimission day (mL/min/1.73 m²), media (SD) | 52.4 ± 25.01 | 44.43 ± 21.4 | − 0.35 ES (−0.37 to 1.07) | 0.3762 |
| Hospital stay (days), median (range) | 17 (12–30) | 24 (11–60) | − 0.49 ES (−1.22 to 0.23) | 0.0924 |
| 1-year graft survival, n (%) | 10 (100%) | 28 (93.3%) | 0.9333 OR (0.3377–2.5796) | 0.8936 |
| 1-year recipient survival, n (%) | 10 (100%) | 29 (96.6%) | 0.9667 OR (0.3506–2.6656) | 0.9478 |
| Liver | HOPE (N = 10) |
Control (N = 30) |
Odds ratio/Effect size (CI interval) |
p value |
| PNF, n (%) | 0 (0%) | 2 (6.6%) | 0.9633 OR (0.3377–2.5797) | 0.8942 |
| EAD, n (%) | 0 (0%) | 7 (23.3%) | 0.7667 OR (0.2734–2.1501) | 0.6135 |
| Peak AST within 7 days (U/L), median (range) | 344.5 (166–1132) | 637 (124–2100) | −0.82 EF (−1.55 to −0.08) | 0.0060* |
| Peak ALT within 7 days (U/L), median (range) | 330 (122–1350) | 601 (114–1837) | −0.52 EF (−1.24 to 0.20) | 0.1438 |
| Bilirubin on 7 day (mg/dL), media (SD) | 3.14 ± 1.54 | 3.62 ± 3.22 | −0.16 EF (−0.88 to 0.55) | 0.5386 |
| INR on 7 day, median (range) | 1.17 (1.08–1.46) | 1.24 (1.02–1.64) | −0.60 EF (−1.32 to 0.13) | 0.0434* |
| Hospital stay (days), median (range) | 11.5 (7–29) | 12.5 (7–109) | −0.28 EF (−1.00 to 0.44 | 0.2350 |
| 1-year graft survival, n (%) | 10 (100%) | 27 (90%) | 0.9000 OR (0.3248–2.4937) | 0.8394 |
| 1-year recipient survival, n (%) | 10 (100%) | 27 (90%) | 0.9000 OR (0.3248–2.4937) | 0.8394 |
eGFR, Estimated Glomerular Filtration Rate; INR, International normalized ratio; PNF = primary non function; DGF = delay graft function; EAD = early allograft dysfunction; AST = aspartate transaminase; ALT = alanine transaminase.