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. 2020 Apr 8;10:6048. doi: 10.1038/s41598-020-63087-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Change of symptom scores in the course of SCIT. The graphs show the symptom scores before and after SCIT - in SCIT-treated patients without neosensitization to treatment-related components (grey graphs; n = 25) and in SCIT-treated patients with de novo sensitization to therapy-related components (black graphs, n = 7). Only in SCIT-treated patients without neosensitization to treatment-related components, a significant reduction of symptom severity is observed after SCIT (*p < 0.05).