Table 2.

Diagnostic accuracy of 68Ga-PSMA PET/CT among 105 patients with a final diagnosis (BVC) for the presence or absence of bone metastases

	M0 by BVC, n = 88			M1 by BVC, n = 17
	M0	Equivocal	M1	M0	Equivocal	M1	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
Three-point scale by three observers	82	2	4	0	0	17	–	–	–	–
Optimistic analysis: Equivocal result considered M0	84		4	0		17	1.00 (0.81–1.00)	0.96 (0.89–0.99)	0.81 (0.58–0.95)	1.00 (0.96–1.00)
Pessimistic analysis: equivocal result considered M1	82		6	0		17	1.00 (0.81–1.00)	0.93 (0.86–0.98)	0.74 (0.52–0.90)	1.00 (0.96–1.00)

BVC best valuable comparator, CI confidence interval, M0 no bone metastases, Equivocal findings are equivocal for bone metastases, M1 bone metastases present, PPV positive predictive value, NPV negative predictive value