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. 2020 Apr 2;11:399. doi: 10.3389/fphar.2020.00399

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Copyright © 2020 Li, He, Zhang, Yang, Ding, Xu, Gu, Li, Yin and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression analysis of the genes related to hematopoiesis in cultured hematopoietic cells with or without chrysin treatment. (A) Scatter plot of mRNA profile showing upregulated genes in cultured HSCs (26 genes), HSPCs (26 genes), MPPs (28 genes), and PROs (26 genes) with C2968 treatment. The genes exhibiting significant changes in expression compared with the control group are labeled (p < 0.001). (B) Fold changes of relative mRNA expression of the most significant upregulated or downregulated genes in cultured HSCs, HSPCs, MPPs, or PROs with C2968 treatment. All data were normalized to the expression levels in control (DMSO 0.01%) group. Graphs show means ± SD (n = 100 cells). HSCs, hematopoietic stem cells; HSPCs, hematopoietic stem and progenitor cells; MPPs, multipotential progenitor cells; PROs, progenitor cells.